Considerations To Know About ceesdekker

Considerations To Know About ceesdekker

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Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits include things like:

Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination functionality.

‘It absolutely was only a subject of selecting up a guide on mobile biology and beginning to study. I'd originate from a planet of ultra-significant vacuums, cryostats and quantum phenomena, and now I used to be working at home temperature with molecular biology kits.

Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.

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SMC complexes can pass physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion

Several relevant developments adopted, wherever our team founded distinctive transistor variants like single-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into modest proof-of-principle electronic circuits.

2011, initial in vitro measurements of transport throughout only one biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the mechanism of homology recognition in DNA homologous recombination

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1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was according to band bending in the ~0.6 eV bandgap semiconducting nanotube. These knowledge also showed the conductance might be modulated by 6 orders of magnitude by changing the gate cees dekker voltage. The outcome of the perform — a place-temperature transistor produced from one carbon nanotube molecule — were revealed in Mother nature in Could 1998.

[fourteen] In 2005 Dekker became involved with Netherlands-wide discussions about Clever Design and style, a motion that he has because Plainly distanced himself from. Dekker advocates that science and faith usually are not in opposition but is usually harmonized.

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2008, 1st observation of protein-coated DNA translocation by nanopores; solved the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of noise in carbon nanotubes in liquid

Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim on the pore is highlighted in pink, plus a 3D rendering of the motion of the DNA rod is shown.